Urinary methylmalonic acid excretion.
نویسنده
چکیده
منابع مشابه
Vitamin BIZ deficiency and the excretion of ether - soluble acids in the rat
I . Urinary excretion of total ether-soluble acids and of methylmalonic acid was studied in rats on vitamin BI2-deficient diets with and without a vitamin Blz supplement. 2. It was shown that urinary excretion of total ether-soluble acids and methylmalonic acid was increased in vitamin R1,-deficient rats and that this increase was somewhat variable between individual animals, males and females,...
متن کاملStudies on methylmalonic acid in humans. I. Concentrations in serum and urinary excretion in normal subjects after feeding and during fasting, and after loading with protein, fat, sugar, isoleucine, and valine.
Determination of methylmalonic acid (MMA) in serum or urine for evaluation of tissue cobalamin (vitamin B12) deficiency is becoming an important diagnostic procedure. Here I present the first investigation of dietary influence on concentrations of MMA in serum and urine. Everyday meals caused an increase in urinary excretion, whereas the concentration in serum was not increased significantly. I...
متن کاملDevelopment and Validation of a GC-FID Method for Diagnosis of Methylmalonic Acidemia
Background: Urinary organic acids are water-soluble intermediates and end products of the metabolism of amino acids, carbohydrates, lipids, and a number of other metabolic processes. In the hereditary diseases known as organic acidurias, an enzyme or co-factor defect in a metabolic pathway leads to the accumulation and increased excretion of one or more of these acidic metabolites. Gas chromato...
متن کاملTracer studies of the interconversion of R- and S-methylmalonic semialdehydes in man.
Two human subjects were given separate oral doses of sodium [2H6]isobutyrate and [methyl-2H3]thymine and the labelling patterns of urinary metabolites were determined. Ingestion of deuterated isobutyrate resulted in the excretion of 2H5-labelled S-3-hydroxyisobutyric acid, formed on the direct catabolic pathway, and of S- and R-[2H4]-3-hydroxyisobutyric acids, formed by the reduction of S- and ...
متن کاملEffect of vitamin B12 derivatives on urinary excretion of methylmalonic acid in liver diseases.
1. Twenty.one patients with liver diseases were studied for their urinary mehylmalonic acid excretion after a valine load by means of an improved thin layer chromatography. 2. Methylmalonic acid positive cases were found in four out of the ten patients with cirrhosis of the liver, all four with cirrhosis and diabetes mellitus, and none with acute hepatitis of icteric phase. No apparent correlat...
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ورودعنوان ژورنال:
- Blood
دوره 61 1 شماره
صفحات -
تاریخ انتشار 1983